One-pot three-component tandem annulation of 4-hydroxycoumarine with aldehyde and aromatic amines using graphene oxide as an efficient catalyst

Abstract A convenient and efficient solvent-free, facile, one-pot three-component graphene oxide catalysed Medical Thermometers approach has been described for the synthesis of chromeno-[4,3-b]quinolin-6-one derivatives from 4-hydroxycoumarin with aldehydes and aromatic amines.Graphene oxide (GO) has proved to be a new class of heterogeneous carbocatalyst which could be easily recovered and reused up to 5th run without significant loss of its catalytic Vaprizers activity.A broad scope of substrate applicability is offered and a plausible mechanism is also suggested for this developed protocol.